Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.57 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.57 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14977487 | 0.89 | SYK (0.67) | SYK | |
| SCHEMBL14977864 | 0.88 | SYK (0.56) | SYKKCNH2AURKBZAP70MAPK3 | |
| SCHEMBL2714184 | 0.85 | FER (0.47) | SYKKCNH2AURKBZAP70 | |
| SCHEMBL2627400 | 0.79 | SYK (0.83) | SYKKCNH2AURKBZAP70 | |
| SCHEMBL14977695 | 0.78 | SYK (0.67) | SYKKCNH2AURKBZAP70MAPK3 | |
| SCHEMBL16194584 | 0.78 | SYK (0.67) | SYKKCNH2AURKBZAP70 | |
| SCHEMBL16194903 | 0.78 | SYK (0.67) | SYKKCNH2AURKBZAP70 | |
| SCHEMBL14981581 | 0.78 | SYK (0.67) | SYKKCNH2AURKBZAP70 | |
| SCHEMBL16194871 | 0.78 | SYK (0.64) | SYKKCNH2AURKBZAP70 | |
| SCHEMBL1353493 | 0.77 | SYK (1.00) | SYKKCNH2AURKBZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782580-A1 | SELECTIVE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078468-A1 | SELECTIVE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |