Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269601 | 1.00 | TDP1 (0.38) | TDP1GPR35SMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL6982116 | 0.89 | TDP1 (0.40) | TDP1GPR35SMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL4572403 | 0.89 | GPR35 (0.40) | TDP1GPR35SMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL4572413 | 0.84 | GPR35 (0.41) | TDP1GPR35SMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL12446428 | 0.84 | GPR35 (0.44) | TDP1GPR35SMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL6979277 | 0.83 | GPR35 (0.40) | TDP1GPR35SMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL4572414 | 0.83 | GPR35 (0.40) | TDP1GPR35SMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL4572411 | 0.82 | TDP1 (0.37) | TDP1GPR35SMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL12677202 | 0.81 | GPR35 (0.38) | TDP1GPR35SMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL4572402 | 0.76 | TDP1 (0.41) | TDP1GPR35SMN1; SMN2CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450499-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-05-28 | — | — | US | disclosed |