Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 10/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13381777 | 0.78 | MAPT (0.48) | KDM4EMAPTALDH1A1HPGDNR4A1 | |
| SCHEMBL13856751 | 0.78 | ALDH1A1 (1.00) | KDM4EMAPTALDH1A1HPGDNR4A1 | |
| SCHEMBL1101912 | 0.68 | ALDH1A1 (0.66) | KDM4EMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1102247 | 0.68 | POLB (0.66) | KDM4EMAPTALDH1A1NR4A1RECQL | |
| SCHEMBL19079697 | 0.68 | TSHR (0.81) | KDM4EMAPTALDH1A1HPGDNR4A1 | |
| SCHEMBL20807060 | 0.67 | SMN1; SMN2 (0.49) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3457233 | 0.64 | NPC1 (0.67) | SMN1; SMN2 | |
| SCHEMBL3457276 | 0.64 | HTR1A (0.64) | — | |
| SCHEMBL14142931 | 0.64 | HTR1A (0.62) | — | |
| SCHEMBL23964783 | 0.64 | MEN1 (0.50) | KDM4EMAPTALDH1A1HPGDNR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450368-B2 | Heme oxygenase inhibitors, screening methods for heme oxygenase inhibitors and methods of use of heme oxygenase inhibitors for antimicrobial therapy | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450368-B2 | Heme oxygenase inhibitors, screening methods for heme oxygenase inhibitors and methods of use of heme oxygenase inhibitors for antimicrobial therapy | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2013-05-28 | — | — | US | disclosed |