Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966130 | 0.86 | GPR119 (0.54) | GPR119TP53 | |
| SCHEMBL14978024 | 0.85 | TP53 (0.35) | GPR119KCNH2BTKTP53 | |
| SCHEMBL16172053 | 0.83 | TP53 (0.42) | GPR119KCNH2TP53RXFP1 | |
| SCHEMBL14968960 | 0.82 | GPR119 (0.52) | GPR119TP53 | |
| Trifluoroacetic Acid SCHEMBL14966698 | 0.81 | GPR119 (0.43) | GPR119KCNH2TP53RXFP1 | |
| SCHEMBL14978750 | 0.79 | GPR119 (0.39) | GPR119KCNH2TP53RXFP1 | |
| SCHEMBL14978691 | 0.78 | TP53 (0.37) | GPR119TP53RXFP1 | |
| SCHEMBL14965995 | 0.77 | GPR119 (0.44) | GPR119KCNH2 | |
| SCHEMBL14968965 | 0.76 | GPR119 (0.40) | GPR119KCNH2TP53RXFP1 | |
| SCHEMBL14966416 | 0.76 | KCNH2 (0.45) | GPR119KCNH2SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074641-A1 | PIPERIDINYL- SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2013-05-23 | — | — | WO | disclosed |