Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | DPP4 | P27487 | 8/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966666 | 0.86 | GPR119 (0.49) | TP53DPP4GPR119 | |
| SCHEMBL14978690 | 0.85 | GPR119 (0.42) | TP53GPR119BTKKCNH2 | |
| SCHEMBL14978693 | 0.83 | TP53 (0.41) | TP53DPP4GPR119PER2KCNH2 | |
| SCHEMBL14970194 | 0.83 | GPR119 (0.48) | TP53DPP4GPR119 | |
| SCHEMBL14966009 | 0.82 | USP30 (0.34) | TP53BTKPER2 | |
| Trifluoroacetic Acid SCHEMBL14966444 | 0.81 | TP53 (0.36) | TP53DPP4GPR119PER2KCNH2 | |
| SCHEMBL14978756 | 0.79 | PER2 (0.37) | TP53DPP4DPP8DPP7PER2 | |
| SCHEMBL14966714 | 0.77 | GPR119 (0.35) | GPR119 | |
| SCHEMBL16163126 | 0.76 | HRH3 (0.37) | GPR119 | |
| SCHEMBL14966286 | 0.75 | CXCR3 (0.42) | GPR119KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074641-A1 | PIPERIDINYL- SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2013-05-23 | — | — | WO | disclosed |