Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 9/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6440712 | 0.91 | MAPT (0.60) | KAT2BMAPTGLAGAAHTR6 | |
| SCHEMBL29578827 | 0.84 | HCAR3 (0.48) | KAT2BMAPTGLAGAAHTR6 | |
| SCHEMBL9618354 | 0.84 | HCAR3 (0.48) | KAT2BMAPTGLAGAAHTR6 | |
| SCHEMBL29353354 | 0.84 | TDP1 (0.47) | KAT2BMAPTGLAGAAHTR6 | |
| SCHEMBL28673730 | 0.84 | TDP1 (0.47) | KAT2BMAPTGLAGAAHTR6 | |
| SCHEMBL8723933 | 0.83 | TSHR (0.50) | MAPTGLAGAAHTR6TSHR | |
| SCHEMBL25191394 | 0.81 | POLB (0.57) | KAT2BGLAHTR6TSHRPOLB | |
| SCHEMBL11887638 | 0.81 | MAPT (0.55) | MAPTGLAGAAHTR6TSHR | |
| SCHEMBL15221111 | 0.80 | MAPT (0.54) | MAPTGLAGAAHTR6TSHR | |
| SCHEMBL12289538 | 0.79 | MAPT (0.66) | MAPTGLAGAAHTR6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450368-B2 | Heme oxygenase inhibitors, screening methods for heme oxygenase inhibitors and methods of use of heme oxygenase inhibitors for antimicrobial therapy | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2013-05-28 | — | — | US | disclosed |