Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 4/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.30 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.30 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19142385 | 0.80 | NCF1 (0.46) | NCF1HRH3HRH4ACHE | |
| SCHEMBL6077911 | 0.80 | — | — | |
| SCHEMBL24508727 | 0.79 | DRD2 (0.40) | HRH3GNAI3GNAO1GNAI1 | |
| SCHEMBL23946062 | 0.78 | SMN1; SMN2 (0.38) | HRH3MMP1MMP13ADAM17 | |
| SCHEMBL23560441 | 0.78 | NCF1 (0.45) | NCF1HRH3HRH4ACHEGNAI3 | |
| SCHEMBL2611007 | 0.77 | NCF1 (0.43) | NCF1HRH3HRH4ACHE | |
| SCHEMBL4827904 | 0.75 | — | — | |
| SCHEMBL10159401 | 0.75 | HRH3 (0.37) | HRH3GNAI3GNAO1GNAI1 | |
| SCHEMBL125618 | 0.74 | NCF1 (0.50) | NCF1HRH3HRH4ACHEGNAI3 | |
| SCHEMBL10503434 | 0.74 | NCF1 (0.50) | NCF1HRH3HRH4ACHEGNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450315-B2 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2013-05-28 | — | — | US | disclosed |