Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.64 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.64 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.64 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | ARG1 | P05089 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | PPM1B | O75688 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28194073 | 1.00 | CYP1A2 (0.64) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL27970690 | 0.88 | CHRNB2 (0.52) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL8481947 | 0.88 | CHRNB2 (0.52) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL8482485 | 0.88 | CHRNB2 (0.52) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL7823846 | 0.88 | CHRNB2 (0.52) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL7491950 | 0.88 | CHRNB2 (0.52) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL7823845 | 0.88 | CHRNB2 (0.52) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL8481945 | 0.88 | CHRNB2 (0.52) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL7491943 | 0.88 | CHRNB2 (0.52) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 | |
| SCHEMBL7424985 | 0.85 | CYP2D6 (0.64) | CYP1A2CYP2D6ALOX15CYP2C19SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239153-A1 | 9-(1H-IMIDAZOL-5-YL)-1,11-DIHYDROISOCHROMENO[4',3':6,7]NAPHTHO[1,2-D]IMIDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS OF HCV NS5A | Gilead Pharmasset LLC (US) | 2017-11-01 | — | — | EP | disclosed |
| EP-3239152-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2017-11-01 | — | — | EP | disclosed |
| EP-2935279-B1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-2907816-A1 | Condensed imidazolylimidazoles as antiviral compounds | Gilead Pharmasset LLC (US) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014100500-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2013075029-A1 | CONDENSED IMIDAZOLYLIMIDAZOLES AS ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2013-05-23 | — | — | WO | disclosed |