Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481945 | 1.00 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7823846 | 1.00 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7491950 | 1.00 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL27970690 | 1.00 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7491943 | 1.00 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL8481947 | 1.00 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL8482485 | 1.00 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7424981 | 0.88 | CYP2D6 (0.64) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7424991 | 0.88 | CYP2D6 (0.64) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7424985 | 0.88 | CYP2D6 (0.64) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104276991-B | A kind of preparation method of 2 carboxylic acid pyrrolidin derivatives | 浙江九洲药物科技有限公司 | 2018-04-06 | — | — | CN | disclosed |
| US-9902693-B2 | Preparation method for pyrrolidine-2-carboxylic acid derivatives | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2018-02-27 | — | — | US | disclosed |
| US-9902693-B2 | Preparation method for pyrrolidine-2-carboxylic acid derivatives | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2018-02-27 | — | — | US | disclosed |
| US-9902693-B2 | Preparation method for pyrrolidine-2-carboxylic acid derivatives | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2018-02-27 | — | — | US | disclosed |
| US-20160145208-A1 | Preparation method for pyrrolidine-2-carboxylic acid derivatives | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2016-05-26 | — | — | US | disclosed |
| US-20160145208-A1 | Preparation method for pyrrolidine-2-carboxylic acid derivatives | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2016-05-26 | — | — | US | disclosed |
| US-20160145208-A1 | Preparation method for pyrrolidine-2-carboxylic acid derivatives | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2016-05-26 | — | — | US | disclosed |
| EP-3015456-A1 | PREPARATION METHOD FOR PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) | 2016-05-04 | — | — | EP | disclosed |
| EP-3015456-A1 | PREPARATION METHOD FOR PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) | 2016-05-04 | — | — | EP | disclosed |
| EP-0874849-B1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO 1,2-A]PYRAZINE DERIVATIVES | PFIZER (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6284757-B1 | ANTISEROTINONE AGENT | PFIZER INC. | 2001-09-04 | — | — | US | disclosed |
| EP-0982030-A2 | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands | Pfizer Products Inc. (US) | 2000-03-01 | — | — | EP | disclosed |
| US-5942537-A | ADMINISTERING A L-TRANS PYRROLIDINE DERIVATIVE TO INHIBIT THE TRANSPORT OF L-GLUTAMATE OR L-ASPARTATE OR AN EXCITATORY AMINO ACID NEUROTRANSMITTER AWAY FROM A SYNAPSE COMPRISING CONTACTING SYNAPSE WITH PYRROLIDINE DERIVATIVE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-08-24 | — | — | US | disclosed |
| US-5714487-A | 2,7-substituted octahydro-pyrrolo 1,2-a!pyrazine derivatives | PFIZER INC. (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0497895-A1 | METHOD OF INHIBITING THE TRANSPORT OF L-GLUTAMATE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-08-12 | — | — | EP | disclosed |
| WO-1991006536-A1 | METHOD OF INHIBITING THE TRANSPORT OF L-GLUTAMATE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1991-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145208-A1 | Preparation method for pyrrolidine-2-carboxylic acid derivatives | PDHB, HPD, PYCR1 | CHRNB2 3818/4885CHRNA4 4311/4885CHRNB4 4461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.