SCHEMBL14979674

SCHEMBL14979674

COC[C@@H]1CN[C@H](C(=O)OC)C1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.39
CHRNA4 P43681 2/20 0.39
CHRNB4 P30926 1/20 0.39
CHRNA3 P32297 1/20 0.39
CHRNA7 P36544 1/20 0.39
ARG1 P05089 1/20 0.38
KMT2A Q03164 1/20 0.33
CHEK2 O96017 2/20 0.32
CHRM2 P08172 1/20 0.31
CHRM4 P08173 1/20 0.31
CHRM3 P20309 1/20 0.31
DPP4 P27487 1/20 0.31
CYP1A2 P05177 2/20 0.31
CYP2D6 P10635 2/20 0.31
ALOX15 P16050 2/20 0.31
CYP2C19 P33261 2/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30571958 1.00 CHRNB2 (0.39) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
Hydrochloric Acid SCHEMBL30571897 0.98 CHRNB2 (0.38) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL21845198 0.84 CHRNB2 (0.36) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL21845406 0.84 ARG1 (0.35) ARG1DPP4CYP1A2CYP2D6CYP2C19
SCHEMBL25366838 0.83 ARG1 (0.54) ARG1KMT2ACYP1A2CYP2D6ALOX15
SCHEMBL22399152 0.83 ARG1 (0.39) ARG1DPP4CYP1A2CYP2D6ALOX15
SCHEMBL17715175 0.83 ARG1 (0.54) ARG1KMT2ACYP1A2CYP2D6ALOX15
SCHEMBL14979644 0.83 DPP4 (0.42) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL14979667 0.83 DPP4 (0.42) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL19339911 0.83 DPP4 (0.42) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3239152-A1 ANTIVIRAL COMPOUNDS Gilead Sciences, Inc. (US) 2017-11-01 EP disclosed
EP-3239153-A1 9-(1H-IMIDAZOL-5-YL)-1,11-DIHYDROISOCHROMENO[4',3':6,7]NAPHTHO[1,2-D]IMIDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS OF HCV NS5A Gilead Pharmasset LLC (US) 2017-11-01 EP disclosed
EP-2935279-B1 ANTIVIRAL COMPOUNDS GILEAD SCIENCES INC (US) 2017-03-15 EP disclosed
EP-2907816-A1 Condensed imidazolylimidazoles as antiviral compounds Gilead Pharmasset LLC (US) 2015-08-19 EP disclosed
WO-2014100500-A1 ANTIVIRAL COMPOUNDS GILEAD SCIENCES, INC. (US) 2014-06-26 WO disclosed
WO-2013075029-A1 CONDENSED IMIDAZOLYLIMIDAZOLES AS ANTIVIRAL COMPOUNDS GILEAD SCIENCES, INC. (US) 2013-05-23 WO disclosed