Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 17/20 | 0.93 |
| ▸ | CCNH | P51946 | 16/20 | 0.93 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.93 |
| ▸ | CDK1 | P06493 | 2/20 | 0.93 |
| ▸ | CDK2 | P24941 | 2/20 | 0.93 |
| ▸ | CDK9 | P50750 | 2/20 | 0.93 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.93 |
| ▸ | CDK8 | P49336 | 1/20 | 0.93 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.89 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.89 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.89 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.89 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.89 |
| ▸ | CCNK | O75909 | 1/20 | 0.89 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.89 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.89 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.89 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.89 |
| ▸ | EGFR | P00533 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18313531 | 0.98 | CDK7 (0.94) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL29355486 | 0.96 | CDK7 (1.00) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL30337868 | 0.96 | CDK7 (1.00) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL18313553 | 0.96 | CDK7 (1.00) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL23682983 | 0.94 | CDK7 (1.00) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL14979765 | 0.94 | CDK7 (1.00) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL18229934 | 0.94 | CDK7 (1.00) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL29355500 | 0.94 | CDK7 (1.00) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL29434968 | 0.94 | CDK7 (1.00) | CDK7CCNHCDK5CDK1CDK2 | |
| Hydrochloric Acid SCHEMBL29867414 | 0.94 | CDK7 (0.99) | CDK7CCNHCDK5CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153730-A9 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-05-19 | — | — | US | disclosed |
| US-20210300911-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-10981903-B2 | Inhibitors of c-Jun-N-terminal kinase (JNK) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-04-20 | — | — | US | disclosed |
| US-20200087295-A9 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-03-19 | — | — | US | disclosed |
| EP-3569598-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | Dana Farber Cancer Institute, Inc. (US) | 2019-11-20 | — | — | EP | disclosed |
| US-20190248778-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-08-15 | — | — | US | disclosed |
| EP-2822935-B1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | DANA FARBER CANCER INST INC (US) | 2019-05-15 | — | — | EP | disclosed |
| US-20160368910-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-12-22 | — | — | US | disclosed |
| US-20160368910-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-12-22 | — | — | US | disclosed |
| US-9382239-B2 | Inhibitors of c-Jun-N-terminal kinase (JNK) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20140309249-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | Dana-Farber Cancer Intitute, Inc. (US) | 2014-10-16 | — | — | US | disclosed |
| WO-2013074986-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10981903-B2 | Inhibitors of c-Jun-N-terminal kinase (JNK) | CNKSR1, MAPK1, MAP3K1 | CDK7 129/4885CCNH 292/4885CDK5 62/4885 |
| US-20210300911-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | CNKSR1, MAPK1, MAP3K1 | CDK7 129/4885CCNH 292/4885CDK5 62/4885 |
| US-20200087295-A9 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | CNKSR1, MAPK1, MAP3K1 | CDK7 129/4885CCNH 292/4885CDK5 62/4885 |
| US-20220153730-A9 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | CNKSR1, MAPK1, MAP3K1 | CDK7 129/4885CCNH 292/4885CDK5 62/4885 |
| US-20160368910-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | CNKSR1, MAPK1, MAP3K1 | CDK7 129/4885CCNH 292/4885CDK5 62/4885 |
| US-20140309249-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | CNKSR1, MAPK1, MAP3K1 | CDK7 129/4885CCNH 292/4885CDK5 62/4885 |
| US-20190248778-A1 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | CNKSR1, MAPK1, MAP3K1 | CDK7 129/4885CCNH 292/4885CDK5 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.