Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9912806 | 0.81 | BRAF (0.52) | BRAFKDR | |
| SCHEMBL14964595 | 0.79 | BRAF (0.71) | BRAF | |
| SCHEMBL3677097 | 0.75 | L3MBTL1 (0.46) | PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3675993 | 0.71 | BRAF (0.54) | BRAFKDRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13979292 | 0.71 | BRAF (0.61) | BRAFKDRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19233297 | 0.71 | KDR (0.62) | BRAFKDR | |
| SCHEMBL28962329 | 0.71 | KDR (0.55) | BRAFKDRPIK3CA | |
| SCHEMBL9932327 | 0.69 | BRAF (0.63) | BRAFKDR | |
| SCHEMBL19233196 | 0.67 | BRAF (0.58) | BRAFKDR | |
| SCHEMBL29761000 | 0.67 | RET (0.41) | PIK3CAPIK3CBPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013071865-A1 | KINASE MODULATING COMPOUNDS, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF | CENTAURUS BIOPHARMA CO., LTD. (CN) | 2013-05-23 | — | — | WO | disclosed |