Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779487 | 0.88 | KMT2A (0.63) | KMT2AMEN1ATMMAPTHRH3 | |
| SCHEMBL3157148 | 0.81 | HRH3 (0.53) | KMT2AMEN1ATMMAPTHRH3 | |
| SCHEMBL2205792 | 0.79 | MAPT (0.52) | KMT2AMEN1ATMMAPTHRH3 | |
| SCHEMBL27042676 | 0.74 | ABCB1 (0.49) | KMT2AMEN1ATMMAPTHRH3 | |
| SCHEMBL3157382 | 0.73 | POLB (0.50) | KMT2AMEN1ATMHRH3KDM4E | |
| SCHEMBL7957691 | 0.73 | KMT2A (0.60) | KMT2AMEN1ATMMAPTHRH3 | |
| SCHEMBL2873071 | 0.71 | MAPK1 (0.65) | KMT2AMEN1ATMMAPTHRH3 | |
| SCHEMBL7006650 | 0.71 | MAPK1 (0.65) | KMT2AMEN1ATMMAPTHRH3 | |
| SCHEMBL23817958 | 0.71 | ABHD6 (0.59) | — | |
| SCHEMBL27229622 | 0.71 | ABCB1 (0.47) | KMT2AMEN1ATMMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-B1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GLAXOSMITHKLINE IP DEV LTD (GB) | 2013-05-29 | — | — | EP | disclosed |