SCHEMBL4779487

SCHEMBL4779487

C=CC(=O)N1CCc2cc(OC)c(OC)cc2C1

nearest known ligand 0.63

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.63
MEN1 O00255 5/20 0.63
ATM Q13315 1/20 0.63
HRH3 Q9Y5N1 1/20 0.60
MAPT P10636 3/20 0.59
MAPK1 P28482 1/20 0.59
KDM4E B2RXH2 3/20 0.55
HSD17B10 Q99714 3/20 0.55
ALOX15 P16050 1/20 0.55
NPC1 O15118 1/20 0.55
THRB P10828 1/20 0.55
ALDH1A1 P00352 2/20 0.54
GAA P10253 1/20 0.54
MDM2 Q00987 1/20 0.54
PDE4D Q08499 1/20 0.54
NPSR1 Q6W5P4 1/20 0.53
TSHR P16473 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3157148 0.92 HRH3 (0.53) KMT2AMEN1ATMHRH3MAPT
SCHEMBL14980787 0.88 KMT2A (0.52) KMT2AMEN1ATMHRH3MAPT
SCHEMBL2205792 0.86 MAPT (0.52) KMT2AMEN1ATMHRH3MAPT
SCHEMBL7957691 0.83 KMT2A (0.60) KMT2AMEN1ATMHRH3MAPT
SCHEMBL7006650 0.81 MAPK1 (0.65) KMT2AMEN1ATMHRH3MAPT
SCHEMBL2873071 0.81 MAPK1 (0.65) KMT2AMEN1ATMHRH3MAPT
SCHEMBL27042676 0.81 ABCB1 (0.49) KMT2AMEN1ATMHRH3MAPT
SCHEMBL1193532 0.80 MAPK1 (0.63) KMT2AMEN1ATMHRH3MAPT
SCHEMBL5467759 0.80 KMT2A (0.64) KMT2AMEN1ATMHRH3MAPT
SCHEMBL3321214 0.79 KMT2A (0.56) KMT2AMEN1ATMHRH3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12398151-B2 Sumo inhibitor compounds and uses thereof Suvalent Therapeutics, Inc. (US) 2025-08-26 US claimed
US-20220177488-A1 SUMO INHIBITOR COMPOUNDS AND USES THEREOF CIT THERAPEUTICS LLC 2022-06-09 US claimed
EP-3941905-A1 SUMO INHIBITOR COMPOUNDS AND USES THEREOF Suvalent Therapeutics, Inc. (US) 2022-01-26 EP claimed
WO-2020191151-A1 SUMO INHIBITOR COMPOUNDS AND USES THEREOF ONCOVALENT THERAPEUTICS INC. (US) 2020-09-24 WO claimed
EP-3833664-B1 SMAD3 INHIBITORS MOEXA PHARMACEUTICALS LTD (HK) 2026-05-13 EP disclosed
US-20260027124-A1 SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT AND PREVENTION OF FIBROSIS MOEXA PHARMACEUTICALS LTD (CN) 2026-01-29 US disclosed
EP-4558503-A1 SUBSTITUTED IMIDAZO [1, 2-A] PYRIDINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT AND PREVENTION OF FIBROSIS Moexa Pharmaceuticals Limited (HK) 2025-05-28 EP disclosed
US-12090149-B2 SMAD3 inhibitors MOEXA PHARMACEUTICALS LIMITED (CN) 2024-09-17 US disclosed
CN-112689634-B SMAD3 inhibitors 莫扎制药有限公司 2024-07-16 CN disclosed
US-20240131032-A1 AN ACTIVITY-GUIDED MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS THE SCRIPPS RESEARCH INSTITUTE 2024-04-25 US disclosed
US-20240123078-A1 COMPOUNDS AND METHODS FOR MODULATING IMMUNE-RELATED PROTEINS VIVIDION THERAPEUTICS, INC. 2024-04-18 US disclosed
WO-2024017144-A1 SUBSTITUTED IMIDAZO [1, 2-A] PYRIDINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT AND PREVENTION OF FIBROSIS MOEXA PHARMACEUTICALS LIMITED (CN) 2024-01-25 WO disclosed
WO-2017070611-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE (US) 2017-04-27 WO disclosed
WO-2017070611-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE (US) 2017-04-27 WO disclosed
US-20170115303-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE 2017-04-27 US disclosed
US-20170115303-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE 2017-04-27 US disclosed
US-20170115303-A1 CYSTEINE REACTIVE PROBES AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE 2017-04-27 US disclosed
WO-2015078417-A1 PYRROLOPYRIMIDINE COMPOUND AND USE THEREOF IN PREPARATION OF HYPOGLAECEMIC DRUG 四川好医生药业集团有限公司 2015-06-04 WO disclosed
WO-2008022467-A1 2-SUBSTITUTED AZAIN DOLES AND 2 SUBSTITUTED THIENOPYRROLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF LAUTENS MARK (CA) 2008-02-28 WO disclosed
WO-2008022467-A1 2-SUBSTITUTED AZAIN DOLES AND 2 SUBSTITUTED THIENOPYRROLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF LAUTENS MARK (CA) 2008-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260027124-A1 SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT AND PREVENTION OF FIBROSIS NOX4, NOX1, CBR1 KMT2A 3740/4885MEN1 4709/4885ATM 3367/4885
US-20240123078-A1 COMPOUNDS AND METHODS FOR MODULATING IMMUNE-RELATED PROTEINS CD4, ICOS, NFATC1 KMT2A 3779/4885MEN1 4604/4885ATM 2348/4885
US-12090149-B2 SMAD3 inhibitors SMAD3, SMAD2, STAT3 KMT2A 1106/4885MEN1 1059/4885ATM 748/4885
US-20240131032-A1 AN ACTIVITY-GUIDED MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS GSTK1, GSTA2, GSTA1 KMT2A 4030/4885MEN1 4768/4885ATM 2031/4885
US-12398151-B2 Sumo inhibitor compounds and uses thereof SUMO1, SUMO2, SUMO3 KMT2A 1223/4885MEN1 1693/4885ATM 1561/4885
US-20220177488-A1 SUMO INHIBITOR COMPOUNDS AND USES THEREOF SUMO1, SUMO2, SUMO3 KMT2A 1223/4885MEN1 1693/4885ATM 1561/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.