Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205732 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2RAB9AALDH1A1KMT2ANPC1 | |
| SCHEMBL2203800 | 0.87 | HRH3 (0.58) | SMN1; SMN2RAB9AALDH1A1KMT2ANPC1 | |
| SCHEMBL2204698 | 0.82 | KMT2A (0.53) | SMN1; SMN2RAB9AALDH1A1KMT2ANPC1 | |
| SCHEMBL3223071 | 0.80 | POLB (0.64) | SMN1; SMN2RAB9AALDH1A1KMT2ANPC1 | |
| SCHEMBL2204025 | 0.79 | KMT2A (0.54) | SMN1; SMN2RAB9AALDH1A1KMT2ANPC1 | |
| SCHEMBL17197305 | 0.78 | MAPK1 (0.54) | ALDH1A1KMT2ANPC1MAPTNPSR1 | |
| SCHEMBL31316090 | 0.78 | MAPK1 (0.54) | ALDH1A1KMT2ANPC1MAPTNPSR1 | |
| SCHEMBL17197259 | 0.78 | MAPK1 (0.54) | ALDH1A1KMT2ANPC1MAPTNPSR1 | |
| SCHEMBL11296161 | 0.78 | MAPK1 (0.54) | RAB9AALDH1A1KMT2ANPC1MAPT | |
| SCHEMBL14925204 | 0.77 | RAB9A (0.53) | SMN1; SMN2RAB9AALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-B1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GLAXOSMITHKLINE IP DEV LTD (GB) | 2013-05-29 | — | — | EP | disclosed |