Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.59 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.32 |
| ▸ | CDK4 | P11802 | 2/20 | 0.32 |
| ▸ | CCND1 | P24385 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.32 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.32 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.32 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361926 | 0.84 | PARP1 (0.81) | PARP1PARP2ALDH1A1KDM4ELMNA | |
| SCHEMBL12786188 | 0.76 | PARP1 (0.86) | PARP1PARP2ALDH1A1KDM4ELMNA | |
| SCHEMBL14980891 | 0.75 | PARP1 (0.54) | PARP1PARP2CCNE2CDK4CCND1 | |
| Cep-9722 SCHEMBL29374944 | 0.74 | PARP1 (1.00) | PARP1PARP2ALDH1A1KDM4ELMNA | |
| Cep-9722 SCHEMBL3359996 | 0.74 | PARP1 (1.00) | PARP1PARP2ALDH1A1KDM4ELMNA | |
| SCHEMBL12786154 | 0.72 | PARP1 (0.78) | PARP1PARP2ALDH1A1KDM4ECA1 | |
| SCHEMBL14346231 | 0.69 | PARP1 (0.49) | PARP1PARP2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL14980875 | 0.68 | PARP1 (0.68) | PARP1PARP2ALDH1A1KDM4ELMNA | |
| SCHEMBL14980855 | 0.66 | MAPT (0.42) | PARP1PARP2ALDH1A1KDM4ECA1 | |
| SCHEMBL12786120 | 0.66 | PARP1 (0.53) | PARP1PARP2ALDH1A1KDM4ECA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066324-B1 | CYCLOALKANOPYROLOCARBAZOLE DERIVATIVES AND THE USE THEREOF AS PARP, VEGFR2 AND MLK3 INHIBITORS | CEPHALON INC (US) | 2013-05-29 | — | — | EP | disclosed |