Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.81 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12786188 | 0.92 | PARP1 (0.86) | PARP1PARP2KDM4EALDH1A1GAA | |
| Cep-9722 SCHEMBL29374944 | 0.90 | PARP1 (1.00) | PARP1PARP2KDM4EALDH1A1GAA | |
| Cep-9722 SCHEMBL3359996 | 0.90 | PARP1 (1.00) | PARP1PARP2KDM4EALDH1A1GAA | |
| SCHEMBL14980877 | 0.84 | PARP1 (0.59) | PARP1PARP2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL14169516 | 0.81 | PARP1 (0.71) | PARP1PARP2KDM4EALDH1A1GAA | |
| SCHEMBL12786144 | 0.80 | PARP1 (0.82) | PARP1PARP2KDM4EALDH1A1PDE5A | |
| SCHEMBL26485278 | 0.80 | PARP1 (0.68) | PARP1PARP2KDM4EALDH1A1GAA | |
| SCHEMBL3362343 | 0.80 | PARP1 (0.68) | PARP1PARP2KDM4EALDH1A1GAA | |
| SCHEMBL14980875 | 0.80 | PARP1 (0.68) | PARP1PARP2KDM4EALDH1A1GAA | |
| SCHEMBL12786120 | 0.80 | PARP1 (0.53) | PARP1PARP2KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066324-B1 | CYCLOALKANOPYROLOCARBAZOLE DERIVATIVES AND THE USE THEREOF AS PARP, VEGFR2 AND MLK3 INHIBITORS | CEPHALON INC (US) | 2013-05-29 | — | — | EP | disclosed |
| US-20110059959-A1 | NOVEL MULTICYCLIC COMPOUNDS AND THE USE THEREOF | CEPHALON, INC. (US) | 2011-03-10 | — | — | US | disclosed |
| EP-2086525-B1 | METHOD OF RADIO-SENSITIZING TUMORS USING A RADIO-SENSITIZING AGENT | CEPHALON INC (US) | 2010-10-06 | — | — | EP | disclosed |
| US-20080146556-A1 | Method of radio-sensitizing tumors using a radio-sensitizing agent | CEPHALON, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080146556-A1 | Method of radio-sensitizing tumors using a radio-sensitizing agent | CEPHALON, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| WO-2007149451-A2 | CYCLOALKANOPYRROLOCARBAZOLE DERIVATIVES AND THE USE THEREOF AS PARP, VEGFR2 AND MLK3 INHIBITORS | CEPHALON, INC. (US) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146556-A1 | Method of radio-sensitizing tumors using a radio-sensitizing agent | PARP1, PARP3, PARP2 | PARP1 1/4885PARP2 3/4885KDM4E 1000/4885 |
| US-20110059959-A1 | NOVEL MULTICYCLIC COMPOUNDS AND THE USE THEREOF | MLKL, PARP3, PARP1 | PARP1 3/4885PARP2 5/4885KDM4E 2445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.