Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12786120 | 0.82 | PARP1 (0.53) | TSHRKDM4EPARP1ALDH1A1CA1 | |
| SCHEMBL12786189 | 0.80 | PARP1 (0.51) | TSHRKDM4EPARP1ALDH1A1CA1 | |
| SCHEMBL29540464 | 0.69 | MAPT (0.75) | MAPTTSHRKDM4EL3MBTL1ALOX12 | |
| SCHEMBL148312 | 0.69 | MAPT (0.75) | MAPTTSHRKDM4EL3MBTL1ALOX12 | |
| SCHEMBL3361926 | 0.67 | PARP1 (0.81) | TSHRKDM4EPARP1ALDH1A1PARP2 | |
| SCHEMBL14980877 | 0.66 | PARP1 (0.59) | MAPTKDM4EL3MBTL1PARP1ALDH1A1 | |
| SCHEMBL26489650 | 0.66 | ALDH1A1 (0.69) | MAPTKDM4EL3MBTL1ALDH1A1CA1 | |
| SCHEMBL20624146 | 0.64 | PRKCA (0.54) | ALDH1A1HTTHPGDHSD17B10 | |
| SCHEMBL10704403 | 0.62 | ABCB1 (0.60) | TSHRL3MBTL1ALDH1A1ABCB1ATM | |
| SCHEMBL20623419 | 0.62 | PRKCA (0.51) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066324-B1 | CYCLOALKANOPYROLOCARBAZOLE DERIVATIVES AND THE USE THEREOF AS PARP, VEGFR2 AND MLK3 INHIBITORS | CEPHALON INC (US) | 2013-05-29 | — | — | EP | disclosed |