Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 6/20 | 0.34 |
| ▸ | FLT1 | P17948 | 4/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | STK25 | O00506 | 1/20 | 0.34 |
| ▸ | CIT | O14578 | 1/20 | 0.34 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | MUSK | O15146 | 1/20 | 0.34 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4320407 | 0.88 | AURKA (0.58) | AURKAAURKBKDRFLT1NTRK1 | |
| SCHEMBL4320414 | 0.88 | AURKA (0.58) | AURKAAURKBKDRFLT1NTRK1 | |
| SCHEMBL14989042 | 0.83 | AURKA (0.59) | AURKAAURKBKDRFLT1NTRK1 | |
| SCHEMBL14988985 | 0.82 | AURKA (0.46) | AURKAAURKBKDRFLT1FGFR1 | |
| SCHEMBL14989027 | 0.82 | AURKA (0.49) | AURKAAURKBKDRFLT1NTRK1 | |
| SCHEMBL14989071 | 0.82 | AURKA (0.49) | AURKAAURKBKDRFLT1NTRK1 | |
| SCHEMBL14988993 | 0.82 | AURKA (0.54) | AURKAAURKBFLT1FGFR1SMN1; SMN2 | |
| SCHEMBL14989335 | 0.82 | AURKA (0.54) | AURKAAURKBFLT1FGFR1 | |
| SCHEMBL14989222 | 0.81 | AURKA (0.57) | AURKAAURKBKDRFLT1NTRK1 | |
| SCHEMBL14989359 | 0.81 | AURKA (0.53) | AURKAAURKBKDRFLT1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | claimed |