Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14989335 | 0.93 | AURKA (0.54) | AURKAAURKBKCNH2HDAC1CDK5 | |
| SCHEMBL14988993 | 0.93 | AURKA (0.54) | AURKAAURKBKCNH2HDAC1CDK5 | |
| SCHEMBL14989064 | 0.91 | AURKA (0.54) | AURKAAURKBKCNH2HDAC1PDGFRB | |
| SCHEMBL14989042 | 0.90 | AURKA (0.59) | AURKAAURKBCDK5CDK5R1FGFR1 | |
| SCHEMBL14989132 | 0.89 | AURKA (0.56) | AURKAAURKBCDK5CDK5R1FGFR1 | |
| SCHEMBL14989189 | 0.89 | AURKA (0.57) | AURKAAURKBCDK5CDK5R1FGFR1 | |
| SCHEMBL4310288 | 0.88 | AURKA (0.67) | AURKAAURKBKCNH2HDAC1CDK5 | |
| SCHEMBL4310294 | 0.88 | AURKA (0.67) | AURKAAURKBKCNH2HDAC1CDK5 | |
| SCHEMBL4310284 | 0.88 | AURKA (0.67) | AURKAAURKBKCNH2HDAC1CDK5 | |
| SCHEMBL4310280 | 0.88 | AURKA (0.67) | AURKAAURKBKCNH2HDAC1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | claimed |