Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 6/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313389 | 0.90 | AURKA (0.58) | AURKAAURKBKDRITKKDM4E | |
| SCHEMBL4313400 | 0.90 | AURKA (0.58) | AURKAAURKBKDRITKKDM4E | |
| SCHEMBL14989122 | 0.85 | AURKA (0.57) | AURKAAURKBFGFR1PARP1 | |
| SCHEMBL14989091 | 0.84 | AURKA (0.56) | AURKAAURKBKDM4EFGFR1PARP1 | |
| SCHEMBL14989042 | 0.84 | AURKA (0.59) | AURKAAURKBKDRFGFR1 | |
| SCHEMBL14988985 | 0.83 | AURKA (0.46) | AURKAAURKBKDRSMN1; SMN2FGFR1 | |
| SCHEMBL14989199 | 0.82 | AURKA (0.63) | AURKAAURKBFGFR1 | |
| SCHEMBL14989222 | 0.81 | AURKA (0.57) | AURKAAURKBKDRITKFGFR1 | |
| SCHEMBL14989004 | 0.81 | AURKA (0.58) | AURKAAURKBKDRITKFGFR1 | |
| SCHEMBL14989166 | 0.81 | AURKA (0.60) | AURKAAURKBKDRITKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | claimed |