Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | CSK | P41240 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 2/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14988993 | 0.91 | AURKA (0.54) | AURKAAURKBHDAC1KDM4EKCNH2 | |
| SCHEMBL14989335 | 0.91 | AURKA (0.54) | AURKAAURKBHDAC1KCNH2 | |
| SCHEMBL14989359 | 0.91 | AURKA (0.53) | AURKAAURKBHDAC1TNIKPDGFRB | |
| SCHEMBL4307930 | 0.89 | AURKA (0.66) | AURKAAURKBHDAC1CSKMAPK14 | |
| SCHEMBL4307940 | 0.89 | AURKA (0.66) | AURKAAURKBHDAC1CSKMAPK14 | |
| SCHEMBL14989042 | 0.88 | AURKA (0.59) | AURKAAURKBPDGFRBKDR | |
| SCHEMBL14989132 | 0.88 | AURKA (0.56) | AURKAAURKB | |
| SCHEMBL14989189 | 0.87 | AURKA (0.57) | AURKAAURKB | |
| SCHEMBL14989222 | 0.87 | AURKA (0.57) | AURKAAURKBCSKTNIKPDGFRB | |
| SCHEMBL14989004 | 0.86 | AURKA (0.58) | AURKAAURKBCSKTNIKPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | claimed |