Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | ICOSLG | O75144 | 1/20 | 0.44 |
| ▸ | ICOS | Q9Y6W8 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL150223 | 0.88 | CHUK (0.49) | PARP14ROCK2CHUKICOSLGICOS | |
| SCHEMBL149496 | 0.85 | ROCK2 (0.58) | PARP14ROCK2JAK2AURKARPS6KB1 | |
| SCHEMBL149424 | 0.84 | ROCK2 (0.58) | PARP14ROCK2JAK2TTKAURKA | |
| SCHEMBL27998034 | 0.77 | JAK2 (0.47) | JAK2 | |
| SCHEMBL148108 | 0.76 | AURKA (0.48) | JAK2AURKARPS6KB1AURKB | |
| SCHEMBL27982802 | 0.75 | BTK (0.56) | PARP14ROCK2JAK2AURKA | |
| SCHEMBL151157 | 0.73 | NPY5R (0.47) | ROCK2JAK2 | |
| SCHEMBL146141 | 0.73 | JAK2 (0.51) | JAK2 | |
| SCHEMBL149838 | 0.72 | ROCK2 (0.47) | ROCK2JAK2 | |
| SCHEMBL148349 | 0.70 | TERT (0.66) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362065-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
| US-8084620-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-27 | — | — | US | disclosed |
| US-20100160303-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | PARP14 649/4885ROCK2 449/4885CHUK 32/4885 |
| US-20100160303-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | PARP14 649/4885ROCK2 449/4885CHUK 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.