Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 7/20 | 0.52 |
| ▸ | AURKA | O14965 | 7/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | TACR2 | P21452 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14989099 | 0.93 | AURKB (0.56) | AURKBAURKAPLK4HRH3PDPK1 | |
| SCHEMBL4317531 | 0.89 | AURKB (0.66) | AURKBAURKAPLK4TACR2TACR3 | |
| SCHEMBL4317539 | 0.89 | AURKB (0.66) | AURKBAURKAPLK4TACR2TACR3 | |
| SCHEMBL14989042 | 0.89 | AURKA (0.59) | AURKBAURKACDK5CDK5R1 | |
| SCHEMBL14989132 | 0.88 | AURKA (0.56) | AURKBAURKACDK5CDK5R1 | |
| SCHEMBL14989189 | 0.88 | AURKA (0.57) | AURKBAURKACTNNB1TCF7L2MCHR1 | |
| SCHEMBL14988993 | 0.88 | AURKA (0.54) | AURKBAURKACTNNB1TCF7L2MCHR1 | |
| SCHEMBL14989335 | 0.88 | AURKA (0.54) | AURKBAURKAMCHR1CDK5CDK5R1 | |
| SCHEMBL14989222 | 0.87 | AURKA (0.57) | AURKBAURKAPLK4INSRIGF1R | |
| SCHEMBL14989359 | 0.87 | AURKA (0.53) | AURKBAURKAMCHR1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | claimed |