Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 4/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 3/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.30 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1499130 | 0.89 | CPT2 (0.35) | CTSCSLC2A1CTSKCTSBCTSS | |
| SCHEMBL3652410 | 0.88 | CTSC (0.42) | CTSCSLC2A1MCHR1DPP4DPP8 | |
| SCHEMBL1499096 | 0.87 | AAK1 (0.38) | CTSCSLC2A1MCHR1CTSKCTSB | |
| SCHEMBL3654483 | 0.86 | CTSC (0.35) | CTSCCTSKCTSSF2DPP4 | |
| SCHEMBL2072730 | 0.86 | CTSC (0.47) | CTSCCTSK | |
| SCHEMBL3661101 | 0.85 | MGLL (0.36) | MCHR1USP30 | |
| SCHEMBL1499211 | 0.85 | CTSC (0.37) | CTSCSLC2A1MCHR1CTSKCTSB | |
| SCHEMBL1499180 | 0.84 | CCR3 (0.35) | CTSCFFAR1DPP4DPP8DPP7 | |
| SCHEMBL1499084 | 0.84 | CTSC (0.37) | CTSCCTSKCTSBCTSSCTSL | |
| SCHEMBL3656277 | 0.83 | DPP4 (0.38) | MCHR1F2DPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011506421-A | — | — | 2011-03-03 | — | — | JP | claimed |
| EP-2231597-A1 | PEPTIDYL NITRILES AND USE THEREOF AS DIPEPTIDYL PEPTIDASE I INHIBITORS | AstraZeneca AB (SE) | 2010-09-29 | — | — | EP | claimed |
| WO-2009074829-A1 | PEPTIDYL NITRILES AND USE THEREOF AS DIPEPTIDYL PEPTIDASE I INHIBITORS | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | WO | claimed |