Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 4/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.53 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31156705 | 0.83 | RHEB (0.53) | RHEBTRPA1HTR1BMEN1MAPK1 | |
| SCHEMBL1499400 | 0.83 | RHEB (0.73) | RHEBTRPA1HTR1BMEN1MAPK1 | |
| SCHEMBL31156723 | 0.77 | RHEB (0.54) | RHEBTRPA1HTR1BMEN1MAPK1 | |
| SCHEMBL2858360 | 0.76 | RHEB (0.49) | RHEBTRPA1HTR1BMEN1MAPK1 | |
| SCHEMBL4716647 | 0.75 | RHEB (0.69) | RHEBTRPA1HTR1BMEN1MAPK1 | |
| SCHEMBL7447585 | 0.74 | PDE10A (0.44) | RHEBTRPA1HTR1BMEN1MAPK1 | |
| SCHEMBL30681623 | 0.74 | AHR (0.57) | RHEBTRPA1HTR1BMEN1MAPK1 | |
| SCHEMBL23709718 | 0.72 | RHEB (0.79) | RHEBTRPA1HTR1BMEN1MAPK1 | |
| SCHEMBL20536057 | 0.72 | TRPA1 (0.74) | RHEBTRPA1HTR1BMEN1MAPK1 | |
| SCHEMBL23709518 | 0.72 | RHEB (0.73) | RHEBTRPA1HTR1BMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | disclosed |
| US-4960777-A | Anxiolytic agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-10-02 | — | — | US | disclosed |
| US-4877792-A | ANXIOLYTIC AGENTS; ANTICONVULSANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-10-31 | — | — | US | disclosed |
| EP-0237467-A2 | Heteroaryl-oxy-beta-carboline derivatives, their preparation and use as medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-09-16 | — | — | EP | disclosed |