Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | GPR3 | P46089 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenanthridine SCHEMBL8666 | 0.85 | GPR3 (1.00) | KDM4EGPR3ADORA3LMNAMAPT | |
| Phenanthridine SCHEMBL9106884 | 0.85 | GPR3 (1.00) | KDM4EGPR3ADORA3LMNAMAPT | |
| Phenanthridine SCHEMBL30823553 | 0.85 | GPR3 (1.00) | KDM4EGPR3ADORA3LMNAMAPT | |
| Phenanthridine SCHEMBL30914262 | 0.85 | GPR3 (1.00) | KDM4EGPR3ADORA3LMNAMAPT | |
| Phenanthridine SCHEMBL23003530 | 0.83 | GPR3 (0.95) | KDM4EGPR3ADORA3LMNAMAPT | |
| Phenanthridine SCHEMBL460289 | 0.83 | GPR3 (0.95) | KDM4EGPR3ADORA3LMNAMAPT | |
| Phenanthridine SCHEMBL8505090 | 0.83 | GPR3 (0.95) | KDM4EGPR3ADORA3LMNAMAPT | |
| Phenanthridine SCHEMBL2421052 | 0.83 | GPR3 (0.95) | KDM4EGPR3ADORA3LMNAMAPT | |
| Phenanthridine SCHEMBL2422346 | 0.83 | GPR3 (0.95) | KDM4EGPR3ADORA3LMNAMAPT | |
| Phenanthridine SCHEMBL3702845 | 0.83 | GPR3 (0.95) | KDM4EGPR3ADORA3LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073920-B2 | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor | PURDUE RESEARCH FOUNDATION (US) | 2015-07-07 | — | — | US | disclosed |
| US-20130143878-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | PURDUE RESEARCH FOUNDATION (US) | 2013-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143878-A1 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR | KRAS, QDPR, BTD | KDM4E 3525/4885GPR3 2327/4885ADORA3 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.