Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.43 |
| ▸ | RXRB | P28702 | 10/20 | 0.43 |
| ▸ | RXRG | P48443 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.36 |
| ▸ | RPA1 | P27694 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MARS1 | P56192 | 1/20 | 0.33 |
| ▸ | XPO1 | O14980 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14995389 | 0.91 | RXRA (0.43) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL14995536 | 0.90 | RXRA (0.42) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL14995646 | 0.85 | RXRA (0.41) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL14995358 | 0.84 | MARS1 (0.46) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL14995435 | 0.84 | RXRA (0.46) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL14995355 | 0.84 | RXRA (0.41) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL3432282 | 0.84 | RXRA (0.52) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL15004402 | 0.84 | KMT2A (0.59) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL14995626 | 0.83 | RXRA (0.40) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL3434224 | 0.81 | RXRA (0.42) | RXRARXRBRXRGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2785705-A1 | CARBOXAMIDE-SUBSTITUTED HETEROARYL-PYRAZOLES AND THE USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013079586-A1 | CARBOXAMIDE-SUBSTITUTED HETEROARYL-PYRAZOLES AND THE USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2013-06-06 | — | — | WO | disclosed |