Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 6/20 | 0.46 |
| ▸ | BCL2 | P10415 | 4/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.46 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.46 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 2/20 | 0.33 |
| ▸ | LDHB | P07195 | 2/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.33 |
| ▸ | MYLK | Q15746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14995997 | 0.92 | BCL2L1 (0.50) | BCL2L1BCL2MCL1BCL2A1HMGCR | |
| SCHEMBL14995995 | 0.90 | BCL2L1 (0.43) | BCL2L1BCL2MCL1BCL2A1ALOX5 | |
| SCHEMBL13018818 | 0.88 | BCL2L1 (0.55) | BCL2L1BCL2MCL1BCL2A1BACE1 | |
| SCHEMBL14995987 | 0.87 | BCL2L1 (0.51) | BCL2L1BCL2MCL1BCL2A1ALOX5 | |
| SCHEMBL14995998 | 0.84 | BCL2L1 (0.47) | BCL2L1BCL2MCL1BCL2A1ALOX5 | |
| SCHEMBL14995966 | 0.81 | BCL2L1 (0.42) | BCL2L1BCL2MCL1BCL2A1HMGCR | |
| SCHEMBL2622283 | 0.77 | BCL2L1 (0.60) | BCL2L1BCL2MCL1BCL2A1BCL2L2 | |
| SCHEMBL14995965 | 0.75 | BCL2L1 (0.66) | BCL2L1BCL2MCL1BCL2A1LDHA | |
| SCHEMBL25445475 | 0.74 | PRKCE (0.55) | HMGCRALOX5PRKCIPTPN1PTPN11 | |
| SCHEMBL14995975 | 0.73 | HSPA5 (0.40) | BCL2L1BCL2MCL1BCL2A1BCL2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455540-B2 | Gossypol and apogossypol derivatives, preparation thereof and uses thereof | UNIVERSITE DU MAINE (LE MANS) (FR) | 2013-06-04 | — | — | US | disclosed |