Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 2/20 | 0.73 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1499796 | 1.00 | GLO1 (0.73) | GLO1CA1CA2CA4CA7 | |
| SCHEMBL15380703 | 1.00 | GLO1 (0.73) | GLO1CA1CA2CA4CA7 | |
| SCHEMBL28927542 | 0.90 | GLO1 (0.70) | GLO1CA1CA2CA4CA7 | |
| SCHEMBL28015566 | 0.89 | GLO1 (0.68) | GLO1CA1CA2CA4CA7 | |
| SCHEMBL7275158 | 0.88 | GLO1 (0.68) | GLO1CA1CA2CA4CA7 | |
| SCHEMBL11433390 | 0.88 | GLO1 (0.71) | GLO1CA1CA2CA4CA7 | |
| SCHEMBL7275161 | 0.88 | GLO1 (0.68) | GLO1CA1CA2CA4CA7 | |
| SCHEMBL10899685 | 0.88 | GLO1 (0.61) | GLO1CA1CA2CA4CA7 | |
| SCHEMBL10665515 | 0.87 | GLO1 (0.65) | GLO1CA1CA2CA4CA7 | |
| SCHEMBL10665503 | 0.87 | GLO1 (0.65) | GLO1CA1CA2CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106380405-B | A kind of synthetic method of 2- (3- nitrobenzal) isopropyl acetoacetate | 郑州瑞康制药有限公司 | 2019-01-29 | — | — | CN | claimed |
| CN-108707106-A | A kind of Azelnidipine impurity and preparation method thereof | 青岛科技大学 | 2018-10-26 | — | — | CN | claimed |
| CN-106380405-A | A method of synthesizing isopropyl 2-(3-nitrobenzylidene)acetoacetate | 郑州瑞康制药有限公司 | 2017-02-08 | — | — | CN | claimed |
| EP-0167068-B1 | Isopropyl-2[2-(3-trifluoromethylphenoxy)ethyl]ester of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylic acid, process for its preparation, and its use as a medicine | BAYER AG (DE) | 1990-02-28 | — | — | EP | claimed |
| JP-11116570-A | — | — | None | — | — | JP | disclosed |
| CN-110294674-A | A kind of tubular type continuous flow reaction unit and the method for preparing isopropyl acetoacetate | 南通醋酸化工股份有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-106380405-B | A kind of synthetic method of 2- (3- nitrobenzal) isopropyl acetoacetate | 郑州瑞康制药有限公司 | 2019-01-29 | — | — | CN | disclosed |
| CN-106380405-B | A kind of synthetic method of 2- (3- nitrobenzal) isopropyl acetoacetate | 郑州瑞康制药有限公司 | 2019-01-29 | — | — | CN | disclosed |
| CN-106380405-B | A kind of synthetic method of 2- (3- nitrobenzal) isopropyl acetoacetate | 郑州瑞康制药有限公司 | 2019-01-29 | — | — | CN | disclosed |
| CN-108707106-A | A kind of Azelnidipine impurity and preparation method thereof | 青岛科技大学 | 2018-10-26 | — | — | CN | disclosed |
| CN-107840802-A | A kind of preparation technology of isopropyl acetoacetate | 南通醋酸化工股份有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-106380405-A | A method of synthesizing isopropyl 2-(3-nitrobenzylidene)acetoacetate | 郑州瑞康制药有限公司 | 2017-02-08 | — | — | CN | disclosed |
| US-3959292-A | HYPOTENSIVE AGENTS, CORONARY DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-25 | — | — | US | disclosed |
| US-3951994-A | HYPOTENSIVE, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-20 | — | — | US | disclosed |
| US-3951988-A | HYPOTENSIVE, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-20 | — | — | US | disclosed |
| US-3948923-A | HYPOTENSIVE, VASODILATION | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-06 | — | — | US | disclosed |
| US-3946026-A | HYPOTENSIVE AGENTS, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-03-23 | — | — | US | disclosed |
| US-3939171-A | HYPOTENSIVE, VASODILATION | BAYER AKTIENGESELLSCHAFT (DT) | 1976-02-17 | — | — | US | disclosed |
| US-3935220-A | VASODILATION, HYPOTENSIVE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-01-27 | — | — | US | disclosed |
| US-3935223-A | 2-Amino-1,4-dihydropyridine derivatives | BAYER AKTIENGESELLSCHAFT (DT) | 1976-01-27 | — | — | US | disclosed |