SCHEMBL1500503

SCHEMBL1500503

O=S(=O)(O)c1ccc(C2CCC(P(C3CCCCC3)C3CCCCC3)CC2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 7/20 0.49
HTT P42858 4/20 0.49
SMN1; SMN2 Q16637 6/20 0.44
APOBEC3A P31941 1/20 0.43
APOBEC3G Q9HC16 1/20 0.43
ALDH1A1 P00352 3/20 0.40
MAPT P10636 2/20 0.40
TP53 P04637 1/20 0.40
ATM Q13315 1/20 0.40
KMT2A Q03164 3/20 0.39
TSHR P16473 3/20 0.39
MEN1 O00255 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
KDM4E B2RXH2 2/20 0.38
MAPK1 P28482 1/20 0.38
HSD17B10 Q99714 1/20 0.38
POLB P06746 1/20 0.38
XBP1 P17861 1/20 0.37
PTGES2 Q9H7Z7 1/20 0.37
RORC P51449 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1500498 0.98 LMNA (0.48) LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G
SCHEMBL12759075 0.98 LMNA (0.46) LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G
SCHEMBL6268570 0.85 LMNA (0.64) LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G
SCHEMBL21423060 0.85 LMNA (0.64) LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G
SCHEMBL1500496 0.84 LMNA (0.45) LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G
SCHEMBL9326230 0.83 LMNA (0.62) LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G
Hydrochloric Acid SCHEMBL27551258 0.83 LMNA (0.62) LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G
SCHEMBL14537256 0.83 LMNA (0.61) LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G
SCHEMBL29219505 0.83 LMNA (0.50) LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G
SCHEMBL16000715 0.83 LMNA (0.50) LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2242760-B1 SULFONATED ORGANOPHOSPHINE COMPOUNDS AND USE IN HYDROFORMYLATION PROCESSES DOW GLOBAL TECHNOLOGIES LLC (US) 2014-03-05 EP disclosed
EP-2242760-B1 SULFONATED ORGANOPHOSPHINE COMPOUNDS AND USE IN HYDROFORMYLATION PROCESSES DOW GLOBAL TECHNOLOGIES LLC (US) 2014-03-05 EP disclosed
US-8466306-B2 Sulfonated organophosphine compounds and use in hydroformylation processes DOW GLOBAL TECHNOLOGIES LLC (US) 2013-06-18 US disclosed
US-8466306-B2 Sulfonated organophosphine compounds and use in hydroformylation processes DOW GLOBAL TECHNOLOGIES LLC (US) 2013-06-18 US disclosed
US-8466306-B2 Sulfonated organophosphine compounds and use in hydroformylation processes DOW GLOBAL TECHNOLOGIES LLC (US) 2013-06-18 US disclosed
US-20110054203-A1 SULFONATED ORGANOPHOSPHINE COMPOUNDS AND USE IN HYDROFORMYLATION PROCESSES DOW GLOBAL TECHNOLOGIES INC. (US) 2011-03-03 US disclosed
US-20110054203-A1 SULFONATED ORGANOPHOSPHINE COMPOUNDS AND USE IN HYDROFORMYLATION PROCESSES DOW GLOBAL TECHNOLOGIES INC. (US) 2011-03-03 US disclosed
EP-2242760-A1 SULFONATED ORGANOPHOSPHINE COMPOUNDS AND USE IN HYDROFORMYLATION PROCESSES Dow Global Technologies Inc. (US) 2010-10-27 EP disclosed
WO-2009091669-A1 SULFONATED ORGANOPHOSPHINE COMPOUNDS AND USE IN HYDROFORMYLATION PROCESSES DOW GLOBAL TECHNOLOGIES INC. (US) 2009-07-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110054203-A1 SULFONATED ORGANOPHOSPHINE COMPOUNDS AND USE IN HYDROFORMYLATION PROCESSES ORMDL3, IP6K3, ALK LMNA 4629/4885HTT 4445/4885SMN1; SMN2 3694/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.