Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PAK4 | O96013 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | LTK | P29376 | 2/20 | 0.43 |
| ▸ | GRK5 | P34947 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31378796 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2DYRK1AHTTKMT2ADYRK1B | |
| SCHEMBL28370791 | 0.81 | DYRK1A (0.42) | SMN1; SMN2DYRK1AHTTKMT2ADYRK1B | |
| SCHEMBL13905439 | 0.79 | HCAR2 (0.53) | SMN1; SMN2KMT2ADYRK1BALDH1A1KDM4E | |
| SCHEMBL1544265 | 0.79 | HTT (0.47) | SMN1; SMN2DYRK1AHTTDYRK1BKDR | |
| SCHEMBL29862389 | 0.79 | HTT (0.47) | SMN1; SMN2DYRK1AHTTDYRK1BKDR | |
| SCHEMBL29407003 | 0.78 | CCR1 (0.52) | SMN1; SMN2DYRK1AHTTKMT2ADYRK1B | |
| SCHEMBL557234 | 0.78 | CCR1 (0.52) | SMN1; SMN2DYRK1AHTTKMT2ADYRK1B | |
| SCHEMBL208952 | 0.78 | SMN1; SMN2 (0.38) | SMN1; SMN2DYRK1AHTTKMT2ADYRK1B | |
| SCHEMBL4923752 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2DYRK1AHTTKMT2ADYRK1B | |
| SCHEMBL23757065 | 0.75 | KMT2A (0.44) | SMN1; SMN2DYRK1AHTTKMT2ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160208-A1 | DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-06-30 | — | — | US | disclosed |
| US-7902369-B2 | Diaryl-substituted five-membered heterocycle derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-03-08 | — | — | US | disclosed |
| US-7833634-B2 | 1,8-naphthyridine compound and organic light-emitting device using the same | CANON KABUSHIKI KAISHA (JP) | 2010-11-16 | — | — | US | disclosed |
| US-7833634-B2 | 1,8-naphthyridine compound and organic light-emitting device using the same | CANON KABUSHIKI KAISHA (JP) | 2010-11-16 | — | — | US | disclosed |
| US-7833634-B2 | 1,8-naphthyridine compound and organic light-emitting device using the same | CANON KABUSHIKI KAISHA (JP) | 2010-11-16 | — | — | US | disclosed |
| US-20070173507-A1 | Dairyl-substituted five-membered heterocycle derivative | MSD K.K. (JP) | 2007-07-26 | — | — | US | disclosed |
| US-20060286408-A1 | 1,8-Naphthyridine compound and organic light-emitting device using the same | CANON KABUSHIKI KAISHA (JP) | 2006-12-21 | — | — | US | disclosed |
| EP-1726585-A1 | DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160208-A1 | DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE | OPRK1, GRM1, GRIK1 | SMN1; SMN2 867/4885DYRK1A 650/4885HTT 3353/4885 |
| US-20070173507-A1 | Dairyl-substituted five-membered heterocycle derivative | OPRK1, OPRL1, GRM1 | SMN1; SMN2 831/4885DYRK1A 590/4885HTT 3793/4885 |
| US-20060286408-A1 | 1,8-Naphthyridine compound and organic light-emitting device using the same | CCNL2, CDKL1, NCKAP1L | SMN1; SMN2 4528/4885DYRK1A 3449/4885HTT 2320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.