3,5-Diiodothyropropionic Acid

3,5-Diiodothyropropionic Acid

SCHEMBL1501771

O=C(O)CCc1cc(I)c(Oc2ccc(O)cc2)c(I)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PCNA P12004 14/20 1.00
THRA P10827 4/20 0.75
THRB P10828 4/20 0.75
POLB P06746 2/20 0.75
HIF1A Q16665 2/20 0.75
MAPK1 P28482 1/20 0.75
LIG1 P18858 1/20 0.57
RXRA P19793 2/20 0.55
PPARG P37231 2/20 0.55
ABCB11 O95342 1/20 0.55
LMNA P02545 1/20 0.55
CYP1A2 P05177 1/20 0.55
PGR P06401 1/20 0.55
CHRM2 P08172 1/20 0.55
HTR1A P08908 1/20 0.55
ADRA2A P08913 1/20 0.55
ADORA3 P0DMS8 1/20 0.55
AR P10275 1/20 0.55
CYP2C9 P11712 1/20 0.55
GABRA1 P14867 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19663420 0.91 PCNA (0.82) PCNATHRATHRBPOLBHIF1A
SCHEMBL15500034 0.87 PCNA (0.77) PCNATHRATHRBPOLBHIF1A
SCHEMBL14485308 0.87 PCNA (0.77) PCNATHRATHRBPOLBHIF1A
Thyropropic Acid SCHEMBL310201 0.86 PCNA (1.00) PCNATHRATHRBPOLBHIF1A
SCHEMBL5742613 0.85 PCNA (0.74) PCNATHRATHRBPOLBHIF1A
SCHEMBL12642750 0.85 PCNA (0.74) PCNATHRATHRBPOLBHIF1A
SCHEMBL4238467 0.84 THRB (0.73) PCNATHRATHRBPOLBHIF1A
SCHEMBL16126006 0.83 PCNA (1.00) PCNATHRATHRBPOLBHIF1A
SCHEMBL14485250 0.82 PCNA (0.70) PCNATHRATHRBPOLBHIF1A
SCHEMBL12440046 0.82 PCNA (0.69) PCNATHRATHRBPOLBHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 767 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250367148-A1 METHODS FOR TREATING ALLAN-HERNDON-DUDLEY SYNDROME DEXCEL PHARMA TECHNOLOGIES LTD (IL) 2025-12-04 US claimed
US-12390432-B2 Methods for treating allan-herndon-dudley syndrome PriZm, LLC (US) 2025-08-19 US claimed
CN-118834806-B Bifidobacterium longum subspecies longum and application thereof in bacteriostasis, colitis alleviation and inflammatory bone loss improvement 迪辅乐生物(上海)有限公司 2025-06-10 CN claimed
EP-4554629-A1 METHODS AND FORMULATIONS FOR GENE THERAPY, AND FOR COMBINING GENE THERAPY WITH DITPA TREATMENT, OF ALLAN-HERNDON-DUDLEY SYNDROME Prizm, LLC (US) 2025-05-21 EP claimed
CN-119592463-A HMO high-utilization strain dipro-15 迪辅乐生物(上海)有限公司 2025-03-11 CN claimed
CN-119570671-A Application of bifidobacterium animalis in anti-inflammatory, anti-helicobacter pylori and improving obesity, hyperlipidemia and bone loss 迪辅乐生物(上海)有限公司 2025-03-07 CN claimed
CN-119530336-A Screening method of HMO high-utilization-rate strain and high-HMO utilization-rate strain 迪辅乐生物(上海)有限公司 2025-02-28 CN claimed
US-20250066734-A1 CULTURE MEDIUM COMPOSITION FOR MATURATING CARDIOMYOCYTES DERIVED FROM PLURIPOTENT MAMMALIAN STEM CELLS NCARDIA B.V. (NL) 2025-02-27 US claimed
CN-118685300-B Bifidobacterium longum subspecies longum and application thereof in preventing, relieving, regulating or treating lipid metabolism related diseases 迪辅乐生物(上海)有限公司 2025-02-18 CN claimed
CN-118497065-B Bifidobacterium longum subspecies longum and application thereof in bacteriostasis or improvement of intestinal axis inflammation related diseases 迪辅乐生物(上海)有限公司 2025-01-24 CN claimed
EP-1793814-A2 THYROID HORMONE ANALOGS FOR PROMOTING ANGIOGENESIS Ordway Research Institute (US) 2007-06-13 EP claimed
JP-2007505837-A 2007-03-15 JP claimed
EP-1670449-A2 THYROID HORMONE ANALOGS AND METHODS OF USE IN ANGIOGENESIS Ordway Research Institute (US) 2006-06-21 EP claimed
EP-1432310-A4 METHOD TO TREAT CHRONIC HEART FAILURE AND/OR ELEVATED CHOLESTEROL LEVELS USING 3,5-DIIODOTHYROPROPIONIC ACID AND METHOD TO PREPARE SAME UNIV ARIZONA (US) 2006-06-21 EP claimed
WO-2006031922-A2 THYROID HORMONE ANALOGS FOR PROMOTING ANGIOGENESIS ORDWAY RESEARCH INSTITUTE (US) 2006-03-23 WO claimed
US-20050124862-A1 Thyroid hormone analogs and methods of use NANOPHARMACEUTICALS LLC 2005-06-09 US claimed
WO-2005027895-A2 THYROID HORMONE ANALOGS AND METHODS OF USE IN ANGIOGENESIS ORDWAY RESEARCH INSTITUTE (US) 2005-03-31 WO claimed
EP-1432310-A2 METHOD TO TREAT CHRONIC HEART FAILURE AND/OR ELEVATED CHOLESTEROL LEVELS USING 3,5-DIIODOTHYROPROPIONIC ACID AND METHOD TO PREPARE SAME The Arizona Board of Regents on Behalf of the University of Arizona (US) 2004-06-30 EP claimed
US-6534676-B2 Reacting ethyl-3-(3,5-diiodo-4-hydroxyphenyl)- propionate with dianisoleiodonium trifluoroacetate to form ethyl-3-(4'-methoxy-3,5-diiodothyro)-propionate; and reacting the intermediate with hydrogen iodide and glacial acetic acid THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA 2003-03-18 US claimed
WO-2002060389-A2 METHOD TO TREAT CHRONIC HEART FAILURE AND/OR ELEVATED CHOLESTEROL LEVELS USING 3,5-DIIODOTHYROPROPIONIC ACID AND METHOD TO PREPARE SAME THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2002-08-08 WO claimed