Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | ICMT | O60725 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 5/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1501997 | 0.92 | IDO1 (0.51) | IDO1TDO2FYNCYP11B1CYP11B2 | |
| SCHEMBL1501838 | 0.85 | IDO1 (0.53) | IDO1TDO2FYNCYP11B1CYP11B2 | |
| SCHEMBL10983627 | 0.82 | IDO1 (0.44) | IDO1EPHB4CYP11B1CYP11B2 | |
| SCHEMBL593796 | 0.82 | CYP11B1 (0.58) | IDO1CYP11B1CYP11B2 | |
| SCHEMBL1501880 | 0.79 | IDO1 (0.53) | IDO1TDO2FYNCYP11B1CYP11B2 | |
| SCHEMBL1501932 | 0.79 | IDO1 (0.50) | IDO1TDO2FYNCYP11B1CYP11B2 | |
| SCHEMBL1502297 | 0.79 | CYP11B1 (0.46) | IDO1CYP11B1CYP11B2 | |
| SCHEMBL27490347 | 0.78 | TLR8 (0.51) | IDO1ICMTCYP11B1CYP11B2 | |
| SCHEMBL1501843 | 0.77 | IDO1 (0.66) | IDO1TDO2FYNCYP17A1HSD17B1 | |
| SCHEMBL27984310 | 0.75 | CYP11B1 (0.51) | IDO1ICMTCYP11B1CYP11B2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174942-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140323740-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-10-30 | — | — | US | disclosed |
| US-8748469-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-06-10 | — | — | US | disclosed |
| CN-102083429-B | Ido inhibitors | NEWLINK GENETICS | 2014-05-28 | — | — | CN | disclosed |
| US-20110136796-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-06-09 | — | — | US | disclosed |
| CN-102083429-A | Ido inhibitors | NEWLINK GENETICS | 2011-06-01 | — | — | CN | disclosed |
| EP-2291187-A2 | IDO INHIBITORS | Newlink Genetics (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009132238-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323740-A1 | IDO Inhibitors | IDO1, IDO2, INMT | IDO1 1/4885TDO2 4/4885ICMT 737/4885 |
| US-20110136796-A1 | IDO Inhibitors | IDO1, IDO2, INMT | IDO1 1/4885TDO2 4/4885ICMT 737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.