SCHEMBL150221

SCHEMBL150221

CN(Cc1cccc(C#N)c1)[Si](C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEP1A Q16819 1/20 0.48
MEP1B Q16820 1/20 0.48
GLA P06280 1/20 0.45
SLC6A2 P23975 1/20 0.45
SLC6A4 P31645 1/20 0.45
SLC6A3 Q01959 1/20 0.45
CYP19A1 P11511 1/20 0.43
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
HRH3 Q9Y5N1 1/20 0.43
TP53 P04637 1/20 0.41
NR3C1 P04150 1/20 0.41
ALDH1A1 P00352 2/20 0.40
GSK3A P49840 1/20 0.39
GSK3B P49841 1/20 0.39
PDK1 Q15118 1/20 0.39
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
TSHR P16473 1/20 0.39
HTT P42858 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL151355 0.86 MEP1A (0.50) MEP1AMEP1BGLASLC6A2SLC6A4
SCHEMBL153971 0.82 MEP1A (0.53) MEP1AMEP1BGLASLC6A2SLC6A4
SCHEMBL17454810 0.79 AOC3 (0.52) MEP1AMEP1BGLASLC6A2SLC6A4
SCHEMBL129128 0.79 CYP2A6 (0.50) SLC6A2SLC6A4CYP19A1CYP11B1CYP11B2
SCHEMBL28733027 0.78 MEP1B (0.64) MEP1AMEP1BGLASLC6A2SLC6A4
SCHEMBL25489322 0.77 MEP1A (0.48) MEP1AMEP1BGLASLC6A2SLC6A4
SCHEMBL24732798 0.76 MEP1B (0.57) MEP1AMEP1BGLASLC6A2SLC6A4
SCHEMBL28764949 0.75 MEP1A (0.56) MEP1AMEP1BGLASLC6A2SLC6A4
SCHEMBL2774079 0.74 MEP1A (0.49) MEP1AMEP1BGLASLC6A2SLC6A4
SCHEMBL12505597 0.74 MEP1A (0.56) MEP1AMEP1BGLASLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2526149-B1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORP (JP) 2017-03-01 EP disclosed
US-9469710-B2 Polymers functionalized with nitrile compounds containing a protected amino group BRIDGESTONE CORPORATION (JP) 2016-10-18 US disclosed
US-20150148489-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2015-05-28 US disclosed
US-8735494-B2 Polymers functionalized with nitrile compounds containing a protected amino group BRIDGESTONE CORPORATION (JP) 2014-05-27 US disclosed
US-20130085227-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2013-04-04 US disclosed
US-8344066-B2 Polymers functionalized with nitrile compounds containing a protected amino group BRIDGESTONE CORPORATION (JP) 2013-01-01 US disclosed
US-20120296041-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-11-22 US disclosed
US-20120059112-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS COMTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-03-08 US disclosed
EP-2382240-A2 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP Bridgestone Corporation (JP) 2011-11-02 EP disclosed
WO-2010085622-A9 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-12-23 WO disclosed
WO-2010085622-A2 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-07-29 WO disclosed