MEP1A — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4405810	0.72	4/20
SCHEMBL4406084	0.69	3/20
SCHEMBL11811255	0.67	3/20
SCHEMBL4407864	0.65	3/20
SCHEMBL7799512	0.62	3/20
SCHEMBL5639050	0.61	3/20
SCHEMBL1456846	0.60	3/20
SCHEMBL168738	0.58	3/20
Hydrochloric Acid (SCHEMBL15067497)	0.56	3/20
SCHEMBL4836068	0.55	3/20
SCHEMBL11897715	0.55	3/20
SCHEMBL6651857	0.55	3/20
SCHEMBL15142867	0.54	3/20
SCHEMBL12169196	0.54	3/20
SCHEMBL11897734	0.52	3/20
SCHEMBL8965622	0.52	3/20
SCHEMBL7759713	0.51	3/20
SCHEMBL13227044	0.50	3/20
SCHEMBL13430653	0.50	3/20
SCHEMBL9369316	0.48	3/20

Clinical trials — most relevant to MEP1A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Peptide Vaccine Focusing on Prevention of the Recurrence for Bladder Cancer	PHASE2	UNKNOWN
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood Cancers	PHASE2	NOT_YET_RECRUITING
Novel Peptide Vaccination for Patients With Advanced Bladder Cancer	PHASE1	COMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
MEHMO Natural History and Biomarkers	nan	RECRUITING
Rett Syndrome Registry	nan	RECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Human Epilepsy Genetics--Neuronal Migration Disorders Study	nan	RECRUITING
Genetic Identification of Monogenic Disorders in Early-onset Stroke Using Targeted Next Generation Sequencing Panel	nan	COMPLETED
Identification of an Asthma Susceptibility Gene on 3P	nan	COMPLETED
Study of Constitutional Platelet Disease	nan	UNKNOWN
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease	nan	COMPLETED
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Exploring the Genetics of Neuropathic Pain	nan	RECRUITING
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles	nan	ACTIVE_NOT_RECRUITING
Biomarkers in Bone Marrow Samples From Patients With Acute Myeloid Leukemia	nan	COMPLETED
Young Pectus Excavatum Patients and Genetic Defects	nan	COMPLETED
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions	nan	RECRUITING
Genetic and Functional Analysis of Craniometaphyseal Dysplasia (CMD)	nan	RECRUITING
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
Retrospective Natural History Study of Infants and Toddlers With LAMA2-CMD	nan	COMPLETED
Exploration and Verification of DNA Methylolation in Early Screening of Esophageal Cancer	nan	UNKNOWN
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING
Genetics and Psychopathology in the 22q11 Deletion Syndrome	nan	UNKNOWN
Evaluate the Evolution of Body and Scalp Skin Discomfort in Patients With Hereditary Ichthyosis After Wraps (EnvelopIchtyose)	nan	RECRUITING
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks	nan	RECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Phenotype/Genotype Correlations in Neuromuscular Disorders	nan	COMPLETED
Congenital Hemolytic and Dyserythropoietic Anemias	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a MEP1A binder may also engage these)

Protein	Name	Similarity
Q64230	—	1.000	Q64230 →
P28825	—	1.000	P28825 →
Q61847	—	0.986	Q61847 →
P28826	—	0.985	P28826 →
Q90YC2	—	0.984	Q90YC2 →
MEP1B	Meprin A subunit beta	0.982	landscape →
Q8R4K8	—	0.978	Q8R4K8 →
P97333	—	0.978	P97333 →
Q13219	—	0.977	Q13219 →
Q7Z304	—	0.977	Q7Z304 →
Q9CPW0	—	0.977	Q9CPW0 →
Q5NDE7	—	0.977	Q5NDE7 →
ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	0.977	landscape →
Q08761	—	0.976	Q08761 →
Q9VAC5	—	0.976	Q9VAC5 →
Q9QWJ9	—	0.976	Q9QWJ9 →
Q6DYE8	—	0.976	Q6DYE8 →
Q9H4D0	—	0.976	Q9H4D0 →
O93470	—	0.976	O93470 →
Q60472	—	0.976	Q60472 →
Q5RBQ5	—	0.975	Q5RBQ5 →
ENPP3	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	0.974	landscape →
W8E7D1	—	0.974	W8E7D1 →
NRP1	Neuropilin-1	0.974	landscape →
Q9H336	—	0.974	Q9H336 →
Q53H76	—	0.974	Q53H76 →
Q8CGD2	—	0.974	Q8CGD2 →
Q9GMT4	—	0.974	Q9GMT4 →
P07867	—	0.974	P07867 →
Q61592	—	0.973	Q61592 →