Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.43 |
| ▸ | GSR | P00390 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 6/20 | 0.41 |
| ▸ | NOS3 | P29474 | 5/20 | 0.41 |
| ▸ | NOS1 | P29475 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27889814 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL4208039 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL17550 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL28160285 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL5965923 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL936448 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL26623152 | 0.96 | OTC (0.43) | OTCDDAH1GSRNOS2NOS3 | |
| Aspartic Acid SCHEMBL2028617 | 0.96 | GSR (0.45) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL150228 | 0.95 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL27692295 | 0.95 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8535650-B2 | Drug delivery; bioavailability; mixture containing glycerides ,surfactant and stabilizer | SOLIGENIX, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| EP-1460992-B1 | STABILIZED REVERSE MICELLE COMPOSITIONS AND USES THEREOF | DOR BIOPHARMA INC (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1460992-A4 | STABILIZED REVERSE MICELLE COMPOSITIONS AND USES THEREOF | DOR BIOPHARMA INC (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20050079145-A1 | Stabilized reverse micelle compositions and uses thereof | SOLIGENIX, INC. | 2005-04-14 | — | — | US | disclosed |
| EP-1460992-A2 | STABILIZED REVERSE MICELLE COMPOSITIONS AND USES THEREOF | Dor Biopharma Inc. (US) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003047493-A2 | STABILIZED REVERSE MICELLE COMPOSITIONS AND USES THEREOF | DOR BIOPHARMA INC. (US) | 2003-06-12 | — | — | WO | disclosed |