Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 2/20 | 0.44 |
| ▸ | PDE2A | O00408 | 7/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | RUNX1 | Q01196 | 3/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14406941 | 1.00 | CBFB (0.44) | CBFBPDE2AALOX5APFEN1TRPM8 | |
| SCHEMBL14405628 | 0.82 | TRPM8 (0.43) | CBFBPDE2ATRPM8SCN10A | |
| SCHEMBL15021788 | 0.82 | TRPM8 (0.43) | CBFBPDE2ATRPM8SCN10A | |
| SCHEMBL14407052 | 0.74 | TRPM8 (0.59) | PDE2ATRPM8GPR139 | |
| SCHEMBL14405547 | 0.74 | TRPM8 (0.59) | PDE2ATRPM8GPR139 | |
| Hydrochloric Acid SCHEMBL14333228 | 0.73 | TRPM8 (0.58) | PDE2ATRPM8GPR139 | |
| Hydrochloric Acid SCHEMBL14333226 | 0.73 | TRPM8 (0.58) | PDE2ATRPM8GPR139 | |
| SCHEMBL30557811 | 0.72 | PDE2A (0.60) | PDE2AALOX5APFEN1SCN10AGPR139 | |
| SCHEMBL16043293 | 0.72 | PDE2A (0.60) | PDE2AALOX5APFEN1SCN10AGPR139 | |
| SCHEMBL17769060 | 0.72 | PDE2A (0.60) | PDE2AALOX5APFEN1SCN10AGPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096527-B2 | TRPM8 antagonists and their use in treatments | AMGEN INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140171406-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-20140171639-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-8710043-B2 | TRPM8 antagonists and their use in treatments | AMGEN INC. (US) | 2014-04-29 | — | — | US | disclosed |
| US-20130157996-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171639-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | TRPM8, TRPM7, TRPM5 | CBFB 3837/4885PDE2A 1011/4885ALOX5AP 1597/4885 |
| US-20140171406-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | TRPM8, TRPM7, TRPM5 | CBFB 3837/4885PDE2A 1011/4885ALOX5AP 1597/4885 |
| US-20130157996-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | TRPM8, TRPM7, TRPM5 | CBFB 3837/4885PDE2A 1011/4885ALOX5AP 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.