Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596692 | 0.86 | HSP90AA1 (0.34) | HSP90AA1NUDT1HRH4CCNKCDK12 | |
| SCHEMBL931576 | 0.78 | PDK2 (0.37) | HSP90AA1PDK2PDK1 | |
| SCHEMBL443459 | 0.77 | GAA (0.34) | HSP90AA1MGAMGAASIMGAM2 | |
| SCHEMBL1502485 | 0.76 | HSP90AA1 (0.38) | HSP90AA1MGAMGAASIMGAM2 | |
| SCHEMBL445190 | 0.76 | HSP90AA1 (0.37) | HSP90AA1MGAMGAASIMGAM2 | |
| SCHEMBL419121 | 0.76 | HSP90AA1 (0.35) | HSP90AA1PDK1 | |
| SCHEMBL445101 | 0.74 | GAA (0.39) | HSP90AA1MGAMGAASIMGAM2 | |
| SCHEMBL5080669 | 0.74 | HSP90AA1 (0.34) | FLT3PDGFRBKITHSP90AA1NUDT1 | |
| SCHEMBL930617 | 0.73 | HSP90AA1 (0.42) | HSP90AA1 | |
| SCHEMBL16754913 | 0.72 | HSP90AA1 (0.41) | HSP90AA1MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678014-A2 | PROSTATE CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | Synta Pharmaceuticals Corp. (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012141796-A2 | PROSTATE CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-10-18 | — | — | WO | disclosed |
| EP-2298748-A2 | Triazole compounds that modulate HSP90 activity | Synta Pharmaceuticals Corp. (US) | 2011-03-23 | — | — | EP | disclosed |