Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MGAM | O43451 | 2/20 | 0.34 |
| ▸ | SI | P14410 | 2/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL443459 | 0.80 | GAA (0.34) | HSP90AA1HSP90AB1GAAMGAMSI | |
| SCHEMBL14184044 | 0.78 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1GAAKDM4EMAPT | |
| SCHEMBL420051 | 0.76 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1GAA | |
| SCHEMBL2596685 | 0.76 | HSP90AA1 (0.35) | HSP90AA1GAAMTNR1AMTNR1BKDM4E | |
| SCHEMBL1502369 | 0.76 | FLT3 (0.37) | HSP90AA1GAAMGAMSIMGAM2 | |
| SCHEMBL930591 | 0.76 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1GAAMTNR1AMTNR1B | |
| SCHEMBL442579 | 0.76 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1 | |
| SCHEMBL445190 | 0.75 | HSP90AA1 (0.37) | HSP90AA1GAAMGAMSIMGAM2 | |
| SCHEMBL931155 | 0.74 | GAA (0.41) | HSP90AA1HSP90AB1GAAKDM4EMAPT | |
| SCHEMBL931757 | 0.74 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1GAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678014-A2 | PROSTATE CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | Synta Pharmaceuticals Corp. (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012141796-A2 | PROSTATE CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-10-18 | — | — | WO | disclosed |
| EP-2298748-A2 | Triazole compounds that modulate HSP90 activity | Synta Pharmaceuticals Corp. (US) | 2011-03-23 | — | — | EP | disclosed |