Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11111501 | 0.73 | KMT2A (0.41) | CYP2C19LMNATHRBMAPTKMT2A | |
| SCHEMBL4278010 | 0.71 | CA12 (0.40) | CYP2C19LMNATHRBKMT2AALDH1A1 | |
| SCHEMBL11110764 | 0.70 | LMNA (0.43) | CYP2C19LMNATHRBKMT2AMEN1 | |
| SCHEMBL3835016 | 0.68 | LMNA (0.60) | RAB9APOLBCYP2C19LMNATHRB | |
| SCHEMBL9441464 | 0.66 | CYP2C19 (0.48) | POLBCYP2C19LMNATHRBKMT2A | |
| SCHEMBL16318735 | 0.66 | CA12 (0.52) | CYP2C19LMNATHRBKMT2ACA12 | |
| SCHEMBL9953609 | 0.65 | LMNA (0.40) | CYP2C19LMNATHRBMAPTKMT2A | |
| SCHEMBL2283075 | 0.64 | LMNA (0.45) | CYP2C19LMNATHRBMAPTKMT2A | |
| SCHEMBL12396373 | 0.64 | KMT2A (0.54) | CYP2C19LMNATHRBKMT2AALDH1A1 | |
| SCHEMBL12396374 | 0.64 | CA12 (0.50) | CYP2C19LMNATHRBKMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170217908-A1 | Benzotriazine Oxides as Drugs Targeting Mycobacterium Tuberculosis | SRI INTERNATIONAL (US) | 2017-08-03 | — | — | US | disclosed |
| US-20170217908-A1 | Benzotriazine Oxides as Drugs Targeting Mycobacterium Tuberculosis | SRI INTERNATIONAL (US) | 2017-08-03 | — | — | US | disclosed |
| US-9663478-B2 | Benzotriazine oxides as drugs targeting Mycobacterium tuberculosis | SRI INTERNATIONAL (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663478-B2 | Benzotriazine oxides as drugs targeting Mycobacterium tuberculosis | SRI INTERNATIONAL (US) | 2017-05-30 | — | — | US | disclosed |
| WO-2013086467-A1 | BENZOTRIAZINE OXIDES AS DRUGS TARGETING MYCOBACTERIUM TUBERCULOSIS | SRI INTERNATIONAL (US) | 2013-06-13 | — | — | WO | disclosed |
| US-20130150369-A1 | Benzotriazine Oxides as Drugs Targeting Mycobacterium Tuberculosis | SRI INTERNATIONAL (US) | 2013-06-13 | — | — | US | disclosed |
| US-20130150369-A1 | Benzotriazine Oxides as Drugs Targeting Mycobacterium Tuberculosis | SRI INTERNATIONAL (US) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217908-A1 | Benzotriazine Oxides as Drugs Targeting Mycobacterium Tuberculosis | QDPR, TBCA, TBCD | NFE2L2 223/4885RAB9A 2300/4885POLB 2119/4885 |
| US-20130150369-A1 | Benzotriazine Oxides as Drugs Targeting Mycobacterium Tuberculosis | QDPR, TBCA, TBCD | NFE2L2 223/4885RAB9A 2300/4885POLB 2119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.