SCHEMBL2596685

SCHEMBL2596685

CCCc1cc2c(-n3c(S)nnc3-c3cc(CC)c(O)cc3O)cccc2[nH]1

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 7/20 0.35
DAO P14920 1/20 0.34
DDO Q99489 1/20 0.34
KDM4E B2RXH2 3/20 0.31
MAPT P10636 2/20 0.31
LMNA P02545 2/20 0.31
MTNR1A P48039 2/20 0.31
MTNR1B P49286 2/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
TSHR P16473 1/20 0.31
HSD17B10 Q99714 1/20 0.31
CTSV O60911 1/20 0.31
CTSL P07711 1/20 0.31
NPEPPS P55786 1/20 0.31
GAA P10253 3/20 0.31
PAX8 Q06710 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13280018 0.85 DAO (0.34) HSP90AA1DAODDOKDM4EMAPT
SCHEMBL2596692 0.82 HSP90AA1 (0.34) HSP90AA1DAODDOKDM4EMAPT
SCHEMBL931450 0.80 ESR1 (0.36) HSP90AA1KDM4EMAPTLMNAGAA
SCHEMBL931385 0.79 HSP90AA1 (0.37) HSP90AA1KDM4EMAPTLMNAALDH1A1
SCHEMBL2596688 0.78 KDM4E (0.38) HSP90AA1KDM4EMAPTLMNAALDH1A1
SCHEMBL929862 0.78 HSP90AA1 (0.38) HSP90AA1KDM4EMAPTLMNAALDH1A1
SCHEMBL1502485 0.76 HSP90AA1 (0.38) HSP90AA1KDM4EMAPTMTNR1AMTNR1B
SCHEMBL930607 0.76 L3MBTL1 (0.39) HSP90AA1KDM4EMAPTLMNAALDH1A1
SCHEMBL421396 0.76 GAA (0.35) HSP90AA1KDM4EMAPTLMNAGAA
SCHEMBL8930902 0.75 GAA (0.34) HSP90AA1KDM4EMAPTLMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2678014-A2 PROSTATE CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS Synta Pharmaceuticals Corp. (US) 2014-01-01 EP disclosed
WO-2012141796-A2 PROSTATE CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2012-10-18 WO disclosed
WO-2011146801-A1 FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2011-11-24 WO disclosed
WO-2008051416-A2 COMPOUNDS THAT INHIBIT THE ACTIVITY OF HSP90 FOR TREATING INFECTIONS SYNTA PHARMACEUTICALS CORP. (US) 2008-05-02 WO disclosed