Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.44 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10605767 | 0.85 | TSHR (0.47) | MAPTKMT2ALMNAKDM4EHSP90AA1 | |
| SCHEMBL11546817 | 0.85 | MAPT (0.55) | MAPTKMT2ALMNAKDM4EHSP90AA1 | |
| SCHEMBL11546810 | 0.85 | MAPT (0.55) | MAPTKMT2ALMNAKDM4EHSP90AA1 | |
| SCHEMBL4778793 | 0.85 | MEN1 (0.57) | MAPTKMT2ALMNAKDM4EHSP90AA1 | |
| SCHEMBL4778791 | 0.85 | MEN1 (0.57) | MAPTKMT2ALMNAKDM4EHSP90AA1 | |
| SCHEMBL11549769 | 0.84 | LMNA (0.64) | MAPTKMT2ALMNAKDM4EHSP90AA1 | |
| SCHEMBL7242741 | 0.84 | CYP1A2 (0.55) | MAPTKMT2ALMNAKDM4EHSP90AA1 | |
| SCHEMBL7242738 | 0.84 | CYP1A2 (0.55) | MAPTKMT2ALMNAKDM4EHSP90AA1 | |
| SCHEMBL11549758 | 0.84 | LMNA (0.64) | MAPTKMT2ALMNAKDM4EHSP90AA1 | |
| SCHEMBL10899651 | 0.83 | LMNA (0.49) | MAPTKMT2ALMNAKDM4EHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284330-B2 | 1,4-dihydro-naphthyridine derivative and pharmaceutical composition and use thereof | JIANGSU SIMOVAY PHARMACEUTICAL CO., LTD. (CN) | 2016-03-15 | — | — | US | disclosed |
| US-20140364443-A1 | 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | JIANGSU SIMOVAY PHARMACEUTICAL CO., LTD. (CN) | 2014-12-11 | — | — | US | disclosed |
| US-20140364443-A1 | 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | JIANGSU SIMOVAY PHARMACEUTICAL CO., LTD. (CN) | 2014-12-11 | — | — | US | disclosed |
| WO-2013083070-A1 | 1, 4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 江苏先声药业有限公司 (CN) | 2013-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364443-A1 | 1,4-DIHYDRO-NAPHTHYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | ACHE, BACE1, CACNA1D | MAPT 181/4885KMT2A 3555/4885LMNA 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.