Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 9/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1502970 | 0.84 | GRM2 (0.50) | GRM2HSD17B10LMNATP53TSHR | |
| SCHEMBL1503055 | 0.81 | GRM2 (0.73) | GRM2CYP3A4 | |
| SCHEMBL6890799 | 0.80 | GRM2 (0.62) | GRM2HSD17B10LMNATP53TSHR | |
| SCHEMBL15168601 | 0.76 | GRM2 (0.46) | GRM2 | |
| SCHEMBL15168876 | 0.74 | PARG (0.39) | GRM2LMNANPSR1MAPTHTT | |
| SCHEMBL1503008 | 0.74 | GRM2 (0.70) | GRM2CYP3A4 | |
| SCHEMBL6891306 | 0.72 | GRM2 (0.52) | GRM2TSHRALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6893791 | 0.72 | GRM2 (0.52) | GRM2TSHRALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6892255 | 0.72 | GRM2 (0.52) | GRM2TSHRALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6890927 | 0.71 | GRM2 (0.75) | GRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |