Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 12/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894402 | 0.89 | GRM2 (0.77) | GRM2CYP3A4HDAC1PARP1GPR119 | |
| SCHEMBL6891655 | 0.86 | GRM2 (0.76) | GRM2CYP3A4HDAC1PARP1GPR119 | |
| SCHEMBL1502959 | 0.86 | GRM2 (1.00) | GRM2CYP3A4HDAC1PARP1 | |
| SCHEMBL6892549 | 0.83 | GRM2 (0.81) | GRM2CYP3A4HDAC1PARP1GPR119 | |
| SCHEMBL6890267 | 0.79 | GRM2 (0.86) | GRM2CYP3A4HDAC1PARP1 | |
| SCHEMBL6894419 | 0.77 | GRM2 (0.83) | GRM2CYP3A4 | |
| SCHEMBL6889485 | 0.76 | GRM2 (0.78) | GRM2CYP3A4 | |
| SCHEMBL6892264 | 0.75 | GRM2 (0.79) | GRM2CYP3A4 | |
| SCHEMBL6893202 | 0.74 | PRMT5 (0.46) | GRM2 | |
| SCHEMBL6892528 | 0.74 | GRM2 (0.78) | GRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |