Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 17/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1502940 | 0.85 | GRM2 (0.64) | GRM2CYP3A4 | |
| SCHEMBL1502978 | 0.85 | GRM2 (0.59) | GRM2CYP3A4CYP2D6CYP1A2TSHR | |
| SCHEMBL1503094 | 0.82 | GRM2 (0.60) | GRM2CYP3A4 | |
| SCHEMBL6889762 | 0.81 | GRM2 (0.60) | GRM2CYP3A4CYP2D6CYP1A2TSHR | |
| SCHEMBL6894481 | 0.80 | GRM2 (0.61) | GRM2CYP3A4CYP2D6CYP1A2TSHR | |
| SCHEMBL1502996 | 0.79 | GRM2 (0.55) | GRM2CYP3A4CYP2D6CYP1A2TSHR | |
| SCHEMBL6891394 | 0.77 | GRM2 (0.70) | GRM2CYP3A4CYP2D6CYP1A2TSHR | |
| SCHEMBL6893183 | 0.76 | GRM2 (0.67) | GRM2 | |
| SCHEMBL1503026 | 0.76 | GRM2 (0.59) | GRM2CYP3A4 | |
| SCHEMBL6893006 | 0.75 | GRM2 (0.58) | GRM2CYP3A4ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | claimed |
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |