Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889762 | 0.96 | GRM2 (0.60) | GRM2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1502940 | 0.91 | GRM2 (0.64) | GRM2CYP3A4 | |
| SCHEMBL1503094 | 0.86 | GRM2 (0.60) | GRM2CYP3A4 | |
| SCHEMBL1502955 | 0.85 | GRM2 (0.54) | GRM2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6894481 | 0.83 | GRM2 (0.61) | GRM2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1502996 | 0.81 | GRM2 (0.55) | GRM2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6891394 | 0.80 | GRM2 (0.70) | GRM2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6893183 | 0.79 | GRM2 (0.67) | GRM2 | |
| SCHEMBL1503026 | 0.79 | GRM2 (0.59) | GRM2CYP3A4 | |
| SCHEMBL6893006 | 0.78 | GRM2 (0.58) | GRM2CYP3A4ALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | claimed |
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |