Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 13/20 | 0.60 |
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894481 | 0.96 | GRM2 (0.61) | GRM2RETEIF2AK4CYP3A4 | |
| SCHEMBL1503026 | 0.93 | GRM2 (0.59) | GRM2RETEIF2AK4CYP3A4 | |
| SCHEMBL1502940 | 0.90 | GRM2 (0.64) | GRM2CYP3A4 | |
| SCHEMBL1502978 | 0.86 | GRM2 (0.59) | GRM2CYP3A4 | |
| SCHEMBL1503048 | 0.84 | GRM2 (0.68) | GRM2CYP3A4 | |
| SCHEMBL6894118 | 0.83 | GRM2 (0.61) | GRM2CYP3A4 | |
| SCHEMBL6889762 | 0.83 | GRM2 (0.60) | GRM2CYP3A4 | |
| SCHEMBL1502955 | 0.82 | GRM2 (0.54) | GRM2CYP3A4 | |
| SCHEMBL6891394 | 0.81 | GRM2 (0.70) | GRM2CYP3A4 | |
| SCHEMBL1503001 | 0.81 | GRM2 (0.58) | GRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |