Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.41 |
| ▸ | PARG | Q86W56 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 8/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503233 | 0.79 | GRM2 (0.46) | GRM2PARGTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL6891297 | 0.76 | GRM2 (0.47) | GRM2PARGLMNA | |
| SCHEMBL1503038 | 0.72 | GRM2 (0.61) | GRM2PARGTSHRNPSR1LMNA | |
| SCHEMBL1502974 | 0.72 | GRM2 (0.64) | GRM2PARGTSHRNPSR1ALDH1A1 | |
| SCHEMBL1502968 | 0.72 | GRM2 (0.64) | GRM2PARGTSHRNPSR1ALDH1A1 | |
| SCHEMBL14857400 | 0.71 | GRM2 (0.66) | GRM2PARG | |
| SCHEMBL6891162 | 0.70 | GRM2 (0.50) | GRM2PARGTSHRNPSR1ALDH1A1 | |
| SCHEMBL6892275 | 0.69 | GRM2 (0.69) | GRM2PARGTSHRNPSR1ALDH1A1 | |
| SCHEMBL15168315 | 0.69 | GRM2 (0.50) | GRM2PARG | |
| SCHEMBL15180696 | 0.69 | GRM2 (0.55) | GRM2PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | claimed |
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |