Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 8/20 | 0.46 |
| ▸ | PARG | Q86W56 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1502957 | 0.79 | GRM2 (0.41) | GRM2PARGALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6891297 | 0.77 | GRM2 (0.47) | GRM2PARGMAPTGRIN1GRIN2B | |
| SCHEMBL1502974 | 0.77 | GRM2 (0.64) | GRM2PARGALDH1A1MAPTTSHR | |
| SCHEMBL1502926 | 0.77 | GRM2 (0.64) | GRM2PARGALDH1A1MAPTTSHR | |
| SCHEMBL1502968 | 0.77 | GRM2 (0.64) | GRM2PARGALDH1A1MAPTTSHR | |
| SCHEMBL1503038 | 0.75 | GRM2 (0.61) | GRM2PARGMAPTTSHR | |
| SCHEMBL6891306 | 0.75 | GRM2 (0.52) | GRM2PARGALDH1A1GAATSHR | |
| SCHEMBL6893791 | 0.75 | GRM2 (0.52) | GRM2PARGALDH1A1GAATSHR | |
| SCHEMBL6892255 | 0.75 | GRM2 (0.52) | GRM2PARGALDH1A1GAATSHR | |
| SCHEMBL1502970 | 0.73 | GRM2 (0.50) | GRM2PARGALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | claimed |
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |